I-81 is the most direct route to SU’s campus. I-81 runs north-south through central and northern New York State. The east-west New York State Thruway, Interstate 90, crosses I-81 just north of Syracuse. Interstate 690 (I-690), another major east-west highway, crosses I-81 in the downtown area.
From I-81: Take Exit 17, East Brighton Avenue. Turn right onto South State Street. Turn right onto East Colvin Street heading east, up the hill, toward Manley Field House. Turn left onto Comstock Avenue to the east side of campus.
Alternate Route (I-81): Take Exit 18, Adams Street. Follow Adams Street eastbound up the hill to University Avenue. A right turn onto University Avenue leads to the center of campus.
From New York State Thruway (I-90): Take Exit 36 for I-81 and downtown Syracuse. Head south on I-81 to the Adams Street exit (Exit 18). Continue directions from above (I-81).
From the west on I-690: Take Exit 14, Teall Ave. Bear right off the exit onto Teall Ave. Turn right at the light, onto Erie Blvd. East. Go approximately one-half mile and turn left onto University Ave., which leads to the center of campus. Turn left onto Harrison St. University Ave. garage is on right.
From the east on I-690: Take Exit 14, Teall Ave., and turn left onto Teall. Turn right at the light, onto Erie Blvd. East. Go approximately one-half mile and turn left onto University Ave., which leads to the center of campus. Turn left onto Harrison St. University Ave. garage is on right.
From Hancock Airport north of the city, proceed to the ramp for I-81 south to Syracuse, head south on I-81 to the Adams Street exit (Exit 18). Continue directions from above.
Be aware of inclement weather while traveling to Syracuse University. Make sure you provide yourself which ample time to travel to Syracuse University.
Credits: https://commencement.syr.edu/getting-to-campus/directions/